News

We would like to announce our upcoming Life after PhD (LAP) seminar, which will take place on Tuesday, 11.5.2021 at 4:30 pm on Zoom (the link is available from compcancer at charite dot de).

Our guest will be Dr. Bastian Gastl, who will share insights into his career path and current occupation as a Medical Science Liaison at Novocure. After having worked at a bank for a short time, he decided to switch gears entirely and did his Bachelor’s degree in Biology at the Ludwigs-Maximilians Universität in Munich. Following up on this, Bastian pursued his Master’s degree at Charité in Molecular Medicine. He extended his stay at Charité by doing his PhD in the group for Molecular Tumorpathology, focusing on effects of reduced DNA replication efficiency in KRAS-mutatant colorectal cancer cell models. When looking for interesting positions outside of academia after finishing his PhD, he first took up work as a Digital Business Consultant, before changing for his current job at Novocure.

Join us to find out about Bastian’s experiences on this way and get tips and hints for perspectives after completing your PhD!

Best wishes,

Wiebke (IRTG2403), Juliane (IRTG2290), and Pamela (CompCancer/ RTG2424)

For more information about this series, visit the IRTG 2403 website: https://www.regulatory-genome.hu-berlin.de/en/events/lectures/lap-series

The upcoming CompCancer Seminar will be hosted by Louisa Krützfeldt from the Schulte group. Find the invitation below. The link is available from compcancer at charite dot de.

Dear all,

I would like to announce next week's CompCancer seminar on May 5th at 4 pm (CET). Adriana Salcedo from the Ontario Institute for Cancer Research will present her paper "A community effort to create standards for evaluating tumor subclonal reconstruction".

https://www.nature.com/articles/s41587-019-0364-z

I invite you to read this interesting publication and collect your questions. Please feel free to share the information with anyone who might be interested in.

Please note that the Journal Club will be at 4 pm, not at 10 am as usual!

Best regards,

Louisa

The upcoming CompCancer Seminar will be hosted by Clemens Messerschmidt from the Leser group. Find the invitation below. The link is available from compcancer at charite dot de.

Dear compcancer members,

Next Wednesday (2021-03-31) at 10:00, Samantha Praktiknjo will join us for our seminar to present her paper

"Tracing tumorigenesis in a solid tumor model at single-cell resolution".

https://www.nature.com/articles/s41467-020-14777-0

The publication describes work done as a senior scientist in Nikolaus Rajewsky's group at the BIMSB.

Recently, she has joined the the newly established Single-Cell Research Focus Area as an Associate Group Leader at the BIH, Charité and MDC .

https://www.mdc-berlin.de/content/single-cell-approaches-personalized-medicine

For this reason, they are eager to learn what others in Berlin are doing in the field, and are looking forward to identifying potentially interesting collaboration opportunities.

Best regards and hope to see you next week,

Clemens

Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging

Wanja Kassuhn, Oliver Klein, Silvia Darb-Esfahani, Hedwig Lammert, Sylwia Handzik, Eliane T. Taube, Wolfgang D. Schmitt, Carlotta Keunecke, David Horst, Felix Dreher, Joshy George, David D. Bowtell, Oliver Dorigo, Michael Hummel, Jalid Sehouli, Nils Blüthgen, Hagen Kulbe, and Elena I. Braicu

Cancers, 2021

High-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian carcinomas with sobering survival rates. The mechanisms mediating treatment efficacy are still poorly understood with no adequate biomarkers of response to treatment and risk assessment. This variability of treatment response might be due to its molecular heterogeneity. Therefore, identification of biomarkers or molecular signatures to stratify patients and offer personalized treatment is of utmost priority. Currently, comprehensive gene expression profiling is time- and cost-extensive and limited by tissue heterogeneity. Thus, it has not been implemented into clinical practice. This study demonstrates for the first time a spatially resolved, time- and cost-effective approach to stratifying HGSOC patients by combining novel matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) technology with machine-learning algorithms. Eventually, MALDI-derived predictive signatures for treatment efficacy, recurrent risk, or, as demonstrated here, molecular subtypes mightbe utilized for emerging clinical challenges to ultimately improve patient outcomes.

https://www.mdpi.com/2072-6694/13/7/1512/pdf

The upcoming CompCancer Seminar will be hosted by Rosario Astaburuaga García from the Blüthgen lab. Find the invitation below. The link is available from compcancer at charite dot de.

Dear all,

On March 10th at 4:30 pm, Vito Zanotelli will present his paper “A quantitative analysis of the interplay of environment, neighbourhood, and cell state in 3D spheroids" in our Journal Club. I invite you to read this interesting publication and collect your questions. 

Also, Vito is now working as Data Scientist in a company (D ONE, Data Driven Value Creation), so if you have questions regarding his “life after Ph.D.” or something like that, you are very welcome to ask.

Best,

Rosario Astaburuaga García